• In order to determine whether the

  2022-12-02

  

  In order to determine whether the faster Rh2-induced apoptosis is specific of cholesterol depletion, we determined the cytotoxic effect of Rh2 in byl719 depleted or not in sphingomyelin, another abundant plasma membrane lipid exhibiting enrichment in lipid rafts. We showed that, in contrast to chol

• Introduction Preeclampsia a serious hypertensive disorder th

  2022-12-02

  

  Introduction Preeclampsia, a serious hypertensive disorder that can occur during pregnancy, is a pregnancy-related disease characterized by the onset of Imiquimod and proteinuria after the 20 t h week of gestation, and it occurs in about 5% of all pregnancies [1]. If left untreated, preeclampsia c

• Overall the expression of both

  2022-12-02

  

  Overall, the expression of both components (ligand and receptor) of the apelin signaling system allows for analysis of the direct role of apelin in CL function, and specifically P4 production. Although the CL secretes many different hormones, P4 is of predominant importance because it is necessary f

• Boc-Phe-Osu Several strategies have been employed to design

  2022-12-02

  

  Several strategies have been employed to design and engineer peptide biosensors of kinase activity, which are quite different from the strategies developed to generate genetically encoded KARs. In all cases, Boc-Phe-Osu induces changes in the spectral properties of the fluorophore(s) incorporated in

• To elucidate this relationship we

  2022-12-02

  

  To elucidate this relationship, we developed a spatial model of Ca-influx through N-methyl-D-aspartate receptor (NMDAR), CaMKII/PP1 activation, and AMPAR insertion in a realistic spine geometry. Using this model, we show that i) variables in membrane voltage mediated Ca-influx, particularly the numb

• br Conflict of interest statement br Acknowledgements We are

  2022-12-01

  

  Conflict of interest statement Acknowledgements We are very grateful to Maura Agate for her excellent editorial assistance. The work reported in this article was supported largely by the Italian MIUR. Introduction Atenolol is a selective β1-adrenergic receptor blocker that is orally effect

• Sphingolipids such as ceramides and glucosylceramides are an

  2022-12-01

  

  Sphingolipids, such as ceramides and glucosylceramides, are an important class of bioactive lipids. The levels of these lipids change as a function of adipose tissue mass and functionality, and are partially driven by cellular availability of palmitoyl-CoA. Aberrant accumulation of ceramide, glucosy

• The subdivision of HT receptors started in the s

  2022-12-01

  

  The subdivision of 5-HT receptors started in the 1950s by Gaddum and colleagues, when they realised that in the guinea pig ileum, the effects of 5-HT could be blocked in part by morphine (M), and in part by dibenzyline (D). Gaddum and Picarelli proposed two receptor classes, 5-HT M and 5-HT D (1957)

• Cy5 Firefly All consecutive patients who were confirmatively

  2022-12-01

  

  All consecutive patients who were confirmatively diagnosed with MP-PPE and TPE, respectively, between January 2008 and December 2016 at Kyungpook National University Hospital, a tertiary referral hospital in South Korea, an area with an intermediate prevalence of active tuberculosis, were enrolled.

• In order to improve the

  2022-12-01

  

  In order to improve the methodology of the synthesis of steroidal derivatives, our goal was the investigation of aza-Michael addition of different N-nucleophiles to 16-dehydropregnenolone in the presence of [DBU][OAc] as catalyst and reaction medium. Michael addition of electron deficient steroidal

• Although CP has been an important

  2022-12-01

  

  Although CP has been an important research subject in the field of antigen processing and presentation, the mechanisms of presentation of intracellular Cephalexin by MHC II received considerably less attention. Interestingly, pioneering work by the Münz laboratory has pointed to an involvement of au

• Here we investigate the ATM to ATR switch in normal

  2022-12-01

  

  Here, we investigate the ATM to ATR switch in normal human fibroblasts (82-6 cells) after irradiation with γ-rays, or high LET 56Fe and 28Si and moderate LET 16O particles. Our data provide important evidence of LET dependence on the transition of ATM to ATR as well as end resection at the sites of

• ionophore Recruitment of the Rad BP mediator

  2022-12-01

  

  Recruitment of the Rad9/53BP1 mediator to ionophore involves multiple pathways (Fig. 2). In unperturbed conditions, Rad9 is already bound to chromatin via interaction between its Tudor domain and methylated histone H3 at lysine 79 [82], [83], [84], [85]. This constitutive Rad9 recruitment to chroma

• br Author contribution br Acknowledgement br Introduction Si

  2022-12-01

  

  Author contribution Acknowledgement Introduction Since the initial finding of Gould et al. [1], showing the loss of dendritic spines in the hippocampus after ovariectomy and its rescue after treatment of the animals with estradiol, a tremendous number of studies have demonstrated a role of

• The presence of crown like structures and

  2022-12-01

  

  The presence of crown-like structures and inflammatory factors in the breast of obese patients is associated with considerable changes in intracellular signaling and a profound cellular dysfunction. Secreted pro-inflammatory factors can directly promote breast carcinogenesis as they have been report

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