• The analysis of the profile of protein phosphorylation

  2024-05-20

  

  The analysis of the profile of protein phosphorylation in MMS-treated Gallein confirmed that both the ATM and ATR pathways were activated in S-phase blocked cells. Interestingly, phosphorylation of Chk1 was observed 24h after MMS-treatment both in AT- and ATM-inhibited cells, whilst in the absence

• The downstream targets of ATR involved in mediating human

  2024-05-20

  

  The downstream targets of ATR involved in mediating human telomerase recruitment have not yet been identified. Under stalled fork conditions, activated ATR is able to phosphorylate and activate ATM (Stiff et al., 2006, and Figures 4C and 4D); whether this comt inhibitors of ATM participates in a po

• br Physiology of the apelin pathway br

  2024-05-20

  

  Physiology of the apelin pathway Role of apelin in heart disease Both apelin and apelin receptor null mice manifested moderate reduction in cardiac contractile function under basal conditions and their exercise capacity was markedly reduced (Table 1) [56]. Apelin has direct effects on the prop

• Over expression of the inflammatory

  2024-05-20

  

  Over expression of the inflammatory cytokines, MMPs and COX-2 act as an important inducer of chronic inflammation. COX-2 catalyzes the biosynthesis of prostaglandins (PGs), and induced expression was observed in BINA mg stimulated with pro-inflammatory cytokines or bacterial lipopolysaccharide (Kha

• Applications for protein switches are

  2024-05-20

  

  Applications for protein switches are numerous. In diagnostics, protein switches can detect analytes as components of inexpensive homogeneous assays that do not require specialized equipment or time-consuming incubation and washing steps characteristic of immunoassays [8]. Protein switches have als

• The control group participants of

  2024-05-20

  

  The control group participants of the current study were very similar in age to those of Puertas et al. There was no significant correlation between age and enzyme activity over the short age span studied although age-related changes in the activity of ApA and aspartyl aminopeptidase, typically incr

• br Disclosure br Acknowledgments br Introduction Anaplastic

  2024-05-18

  

  Disclosure Acknowledgments Introduction Anaplastic lymphoma kinase (ALK), a receptor tyrosine kinase, belongs to the insulin receptor kinase subfamily [1]. Oncogenic activation of ALK is associated with the 3280 and progression of multiple human cancer types [2,3], including anaplastic lar

• Sperm total motility and hyperactivated motility are

  2024-05-18

  

  Sperm total motility and hyperactivated motility are mediated by PLD-dependent prolyl hydroxylase inhibitor polymerization [20]. Reduction of PIP2 synthesis inhibited actin polymerization and motility, and increasing PIP2 synthesis enhanced these activities. Furthermore, sperm demonstrating low mot

• The first result of this paper is parallel

  2024-05-18

  

  The first result of this paper is parallel to the positivity result given in [16]: Here the definition of approximate ACHE metric is the same as in [18]. See Definition 1 for details. The second result of this paper is parallel to the Etoposide extension formulae given in [2]. In particular, whil

• Considering the physicochemical stability results on Fig it

  2024-05-18

  

  Considering the physicochemical stability results on Fig. 5, it was observed that the particles are stable when they are stored at 4 °C for 30 days. After day 30, a significant increase was observed in particle size, but at the end of the 90 days the SLN particle size is still below 100 nm. Stabilit

• br Materials and methods br Results br Discussion Recent

  2024-05-18

  

  Materials and methods Results Discussion Recent studies have highlighted antibiotics and autophagy as novel targets for the treatment of liver fibrosis [7,14]. In this study, we demonstrated that catalpol protected the rat liver from CCl4-caused injury and fibrogenesis in vivo and in vitro

• In our previous report we synthesized derivatives with some

  2024-05-18

  

  In our previous report, we synthesized derivatives with some straight chain residues on the 2-position of the 3-cyanopyridine ring of compound 1. In this time we tried to introduce aromatic ring on the chain of the 2-position. Namely, we replaced the hydroxyl-alkylamino group in the position 2 of t

• Asunaprevir br Synthetic lethal approaches In addition to t

  2024-05-18

  

  Synthetic lethal approaches In addition to the potential utility of ATM and ATR as chemo- or radiosensitisers, recent studies suggest that such compounds may have single agent activity in certain subsets of patients through induction of synthetic lethality. Two genes are considered synthetically

• Second the choice of the PAABD

  2024-05-17

  

  Second, the choice of the PAABD is critical for an efficient and sensitive biosensor. The sequence of the PAABD should present high affinity and efficient recognition of the phosphorylated substrate, as opposed to poor affinity for the unphosphorylated substrate, and should display a fully reversibl

• Although the interactions of PhLP with G

  2024-05-17

  

  Although the interactions of PhLP with Gβγ and its other partners have been convincingly documented through in vitro studies, it is not clear how PhLP controls Pioglitazone receptor signaling in vivo. C. elegans provides a powerful genetic model to analyze Phosducin function and study its interacti

16250 records 152/1084 page Previous Next First page 上5页 151152153154155 下5页 Last page