• br Materials and methods br Results br Discussion The

  2018-11-08

  

  Materials and methods Results Discussion The mechanisms of ADSC migration are still largely unknown. Migration of ADSCs in vitro is shown to be induced by several chemokines, VEGF, PDGF, LPA and TxA2 through activation of their biologically active receptors (Amos et al., 2008; Baek et al.,

• Here using an ectopic bone

  2018-11-08

  

  Here, using an ectopic bone model system, we found that: i) AFSCs do not contribute to bone healing by osteogenic differentiation or osteo-integration; ii) AFSCs are not retained in the bone microenvironment, do not affect the osteosynthesis, and do model the site in terms of vascular perfusion; iii

• In this study we used dermal fibroblasts

  2018-11-08

  

  In this study we used dermal fibroblasts derived from three different patients with distinct mutations in the TAZ1 gene (Houtkooper et al., 2009) and generated BTHS patient-specific iPSCs. We fully characterized them in terms of pluripotency both in vitro and in vivo. Similar to human ESCs, all gen

• In this study hPSC derived

  2018-11-08

  

  In this study hPSC-derived bfCNs were generated via an expandable NSC intermediate, which maintained the desired basal forebrain progenitor phenotype, and neurogenic capacity even after long-term expansion in culture. This scalability is a required feature of any cell type to be used in regenerative

• The potential of ES cells to

  2018-11-08

  

  The potential of ES dna staining to differentiate into DA neurons in vitro offers a simplified model system to dissect the mechanisms of cell intrinsic and extrinsic factors in DA neurogenesis, compared to the complex mammalian CNS (Baizabal and Covarrubias, 2009; Murry and Keller, 2008). Furthermo

• Previous in vitro characterization of compensatory TSC

  2018-11-08

  

  Previous in vitro characterization of compensatory TSC differentiation was performed at 20% O2 with a dose of benzopyrene or hyperosmolar stress that activated maximal stress enzyme (Zhong et al., 2010; Xie et al., 2010). When O2 levels are optimized, the highest growth and the least stress (activat

• br Materials and methods br Results br

  2018-11-08

  

  Materials and methods Results Discussion Recent neurogenesis studies and the discovery of multipotent neural stem purchase mecamylamine derived from the adult mammalian CNS, including that of humans, have had a considerable influence on potential treatments for neural injury (Gross, 2000; M

• br Summary and conclusions br

  2018-11-08

  

  Summary and conclusions Introduction Historically, the foundations of the concept that the heart is a static organ incapable of regeneration were established in the mid-1920s. A significant publication in 1925 claimed that mitotic figures are not detectable in human cardiomyocytes (Karsner et

• br Introduction Developmental myelination and

  2018-11-08

  

  Introduction Developmental myelination and myelin repair after demyelination are mediated by oligodendrocyte precursor cells (OPCs). OPCs are characterized by markers such as PDGFRα and the chondroitin sulfate proteoglycan NG2 (Dubois-Dalcq et al., 2008; Franklin and Ffrench-Constant, 2008; Nishi

• br Introduction The human gallbladder mainly

  2018-11-08

  

  Introduction The human gallbladder mainly functions to concentrate and store bile, and like anatomically close-by organs—the liver and the pancreas—is derived from the foregut endoderm during embryonic development (Spence et al., 2009). The extrahepatic biliary tree (comprising extrahepatic bile

• The DNA fingerprint of Lymph AD iPS cell line was

  2018-11-08

  

  The DNA fingerprint of Lymph2-AD2-iPS cell line was identical to the parental lymphoblast line AD2-2 (Fig. 1D). Karyotype analysis was male (XY) and both lines exhibited a normal diploid chromosomal content (Fig. 1E). As depicted in the Dendrogram (Fig. 1F), the transcriptome of the parental lymphob

• Bioactive Compound Library Human fibroblasts were reprogramm

  2018-11-08

  

  Human fibroblasts were reprogrammed from an individual into nociceptor neurons without creation of iPSCs and the neurons exhibited sensitization to the chemotherapeutic drug oxaliplatin, modeling the inherent mechanisms underlying painful CIPN (Wainger et al., 2015); however, the advantage to creati

• Immunohistochemical studies revealed increase in the proport

  2018-11-08

  

  Immunohistochemical studies revealed increase in the proportion of CD44highCD24low cell type from low in normal tissues to quite high in tumours. This is interesting as we know that Cancer Stem Cells are the actual tumour initiating subpopulation and can expand depending on its evolutionary landscap

• The TSD patient fibroblasts were reprogrammed using the STEM

  2018-11-08

  

  The TSD patient fibroblasts were reprogrammed using the STEMCCA lentivirus, which express OCT4, SOX2, KLF4, and c-MYC (OSKM) from a polycistronic transcript (Somers et al. 2010). TSD-01-hiPSC form colonies typical to human pluripotent stem orexin receptor and express pluripotency markers such as alk

• br Results br Discussion Our

  2018-11-08

  

  Results Discussion Our report represents a genome-wide study to understand the genetic variance in culture-expanded human MSCs. The emergence of multiple low-frequency SNCs in primary marrow MNCs (Figure 2A) indicates the existence of small clones carrying unique private somatic mutations, con

16300 records 1068/1087 page Previous Next First page 上5页 10661067106810691070 下5页 Last page