• In the present study enzyme

  2018-10-24

  

  In the present study, enzyme activity was dispensable for reprogramming and iPSC maintenance. This is in contrast with Fanconi anemia (Raya et al., 2009; Navarro et al., 2014), and also with Sanfilippo type B (Lemonnier et al., 2011) and Pompe disease (Higuchi et al., 2014), in all of which gene com

• The pituitary gland is considered the master gland of hormon

  2018-10-24

  

  The pituitary gland is considered the master gland of hormone function. Hypopituitarism is a disease condition with insufficient or absent function of the pituitary gland. Pituitary tumors are the most common cause but many other triggers can induce pituitary dysfunction including inborn genetic def

• gp120 Main Text Stem cell research remains an

  2018-10-24

  

  Main Text Stem cell research remains an exploding area of investigation with the potential to change human health. As the field continues to grow, so does the ISSCR and its role as the world’s largest professional organization of stem cell scientists. Our mission to promote good science and respons

• br Results br Discussion In the meibomian gland low numbers

  2018-10-24

  

  Results Discussion In the meibomian gland, low numbers of LRCs were observed after 28, 42, and 56 days of chase, which fulfill the slow-cycling, undifferentiated, and low population criteria of adult epithelial stem kit inhibitor characterized in other tissues (Alonso and Fuchs, 2003; Stepp a

• The ensuing replication stress during rapid expansion elicit

  2018-10-24

  

  The ensuing replication stress during rapid expansion elicits a broad DDR, when Fancd2-deficient HSPC accumulate DNA damage and activate p38 MAPK in response to physiological replication demands encountered during development. The lack of a more robust γH2AX phosphorylation seemed initially surprisi

• procyanidin b2 The distinct epigenetic and molecular profile

  2018-10-24

  

  The distinct epigenetic and molecular profile of PDGFRα+ subpopulations was confirmed also by their developmental potential (Figure 5 and Table S1). The double-positive procyanidin b2 could still colonize the epiblast while PrE-primed cells exclusively contributed to PrE derivatives. Again, these i

• β(1,3)-d-glucan synthase GSC reprogramming takes place over

  2018-10-24

  

  GSC reprogramming takes place over multiple weeks and the mechanism is largely unknown. Low efficiency and inconsistent ESL cell formation makes it difficult to study the molecular mechanism of GSC reprogramming, knowledge of which is a prerequisite for improving the efficiency. In addition, GSCs do

• Regardless of the detailed mechanisms of metabolic regulatio

  2018-10-24

  

  Regardless of the detailed mechanisms of metabolic regulation in ESCs, recent studies indicate that reprogramming MEFs into iPSCs involves dramatic changes in cell metabolism from oxidative phosphorylation to glycolysis (Folmes et al., 2011). Somewhat paradoxically, however, the early phase of the m

• Given the importance of the

  2018-10-24

  

  Given the importance of the master regulatory HOX genes for patterning during embryogenesis, we expect that the ectopic expression of a specific HOX code could allow for enhanced development of desired tissues in vitro. One example is human HOXB4, which is highly expressed in the hematopoietic stem

• To investigate whether the activated pathways identified in

  2018-10-24

  

  To investigate whether the activated pathways identified in ALS MNs were causal or merely associated with the disease phenotype, we assayed MN survival in vitro after pharmacological inhibition of the identified pathways. MNs differentiated from mutant SOD1 iPSCs were treated with small-molecule inh

• where a is a radius

  2018-10-24

  

  where a is a radius of the circular contact (probe); r is a distance from the center of the contact – probe place to the hemispherical contact; ρ is a resistivity of the area between the contacts. Spreading resistance R is well approximated for a homogeneous semi-infinite doped sample with resistan

• Acceleration of neutrons in the uniform magnetic field by me

  2018-10-24

  

  Acceleration of neutrons in the uniform magnetic field by means of a radio-frequency flipper is well known and successfully used in physical experiments (see, e.g., Ref. [7]). The phenomenon of neutron acceleration in a strong alternating magnetic field (of amplitude ∼0.4T) was observed in Ref. [8].

• kv1.3 inhibitor The results of epitope mapping and

  2018-10-24

  

  The results of epitope mapping and limited proteolysis are also consistent with the results of computer analysis of the sequence. To date, two alternative topological models have been proposed, differing from each other by the orientation of receptor insertion into the lipid bilayer (Fig. 2b and c)

• br Funding and conflict of interest statements br

  2018-10-24

  

  Funding and conflict of interest statements Acknowledgements We would like to acknowledge funding received from the Canadian Institutes of Health Research (award number GSD-134926) and the Lawson Foundation, Canada (grant number GRT 2011-013). We would also like to thank Dr. Mieke Koehoorn for

• Aside from differences between countries differences also ex

  2018-10-24

  

  Aside from differences between countries, differences also exist within countries. Indeed, recent research shows that in many African countries attitudes related to female genital cutting vary substantially at the individual and household levels (Bellemare et al., 2015; Efferson et al., 2015; Hernlu

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