• br Transparency document br Acknowledgements We thank Prof B

  2019-07-04

  

  Transparency document Acknowledgements We thank Prof. Barbara Brodsky for valuable comments and discussion. We thank the support of the Tufts start-up fund and the Knez Family Faculty Investment Fund for Y.-S. L, and the Tufts Summer Scholar program for E.C. Introduction Discoidin domain r

• In addition to through direct regulation of cell differentia

  2019-07-04

  

  In addition to through direct regulation of cell differentiation, DDR2 may raise the abundance of myofibroblast subsets through advancing the recruitment of its precursor cells. One such evidence is that DDR2 can regulate lung fibroblast proliferation and migration. Another possibility rests on the

• Several TERRA binding proteins have also been discovered

  2019-07-04

  

  Several TERRA-binding proteins have also been discovered, especially telomeric duplex DNA binding proteins TRF1 and TRF2, pointing to a significant role of TERRA in more general chromosome biology [14], [20], [21]. TRF2 is a key component of Shelterin that protect chromosome termini [22]. Telomeres

• MI has been detected in wastewater

  2019-07-03

  

  3MI has been detected in wastewater at concentrations of 640–700 μg L−1 (Hwang et al., 1995) and up to 20 mg L−1 in decaying algal water environments (Peller et al., 2014). It is likely that 3MI accumulation in fish might be due to the degradation of endogenous amino acids. The presence of this che

• br Introduction Type Diabetes mellitus T DM

  2019-07-03

  

  Introduction Type 2 Diabetes mellitus (T2DM) is a metabolic disorder that raises blood glucose level for a prolonged time. T2DM is associated with acute complications like ketoacidosis, hyposmolar coma, chronic complications include heart disease, stroke, kidney failure, foot ulcers and damage to

• Introduction BRs are well known

  2019-07-03

  

  Introduction BRs are well known class of steroid phytohormones involved in the regulation of key processes of plant growth and development [1], [2], [3], [4], [5]. A lot of attention is driven to BRs in the last decade because of their undeniable functions in promoting cyclohexamide reactions of p

• In Senegal malaria remains a formidable public

  2019-07-03

  

  In Senegal, malaria remains a formidable public health issue, causing significant morbidity and mortality in infants and pregnant women (WHO Malaria Report, 2012). In the absence of an effective vaccine, the National Malaria Control Program has followed WHO recommendations for IPTp-SP since 2003. Th

• br Results br Discussion The structures presented here were

  2019-07-03

  

  Results Discussion The structures presented here were solved at high 3-Methyladenine and show in detail how DDR1 achieves high affinity for imatinib and ponatinib, respectively. Both type II inhibitors bind in their more potent extended conformations to the inactive DFG-out conformation of th

• The X ray crystal structure

  2019-07-03

  

  The X-ray crystal structure of palbociclib bound to CDK6 without a SBI-0206965 (PDB ID: 5L2I) is very similar to that of the CDK6-cyclin V structure (Fig. 7B). However, the drug binds to the αCout conformation of monomeric CDK6 while it binds to the αCin conformation of the CDK6-cyclin V complex. I

• There is an increase in small fruit consumption especially

  2019-07-03

  

  There is an increase in small fruit consumption especially berries in recently. Because small fruits are rich sources of both anthocyanins and phenolic compounds. These chemicals have been found in Vaccinium corymbosum in high levels. Research on small fruits is of vital importance for human nutriti

• The significant CRF increase in the DS

  2019-07-03

  

  The significant CRF increase in the DS and the overall changes in the CRF system observed in the VM and DS during the development of sensitization suggest that this neuropeptide (and possibly urocortin) contributes to the specific molecular alterations occurring in the mesolimbic pathway that suppor

• br Common features of TdT pol

  2019-07-02

  

  Common features of TdT, pol μ and pol λ TdT, pol μ and pol λ remain in a closed conformation throughout their catalytic cycle, contrary to pol β [24•, 53, 54•]. One possible explanation for this observation is that they have traded fidelity (which requires open-to-closed transition) for a very ti

• A number of studies have been carried out to understand

  2019-07-02

  

  A number of studies have been carried out to understand lipid production pathways and to increase TAGs level in higher plants. Overexpression of key PR-171 what of the Kennedy pathway until now is by far the most successful strategy to increase TAG lipid content in Brassica napus, Arabidopsis thalia

• It is well established that Shp

  2019-07-02

  

  It is well established that Shp-2 can function as a substrate for several RTK, such as PDGF or EGFR [23], [36]. To test whether DDR1 recognizes Shp-2 as its substrate, we overexpressed a catalytically inactive Shp-2 mutant together with DDR1b in 293 cells [31]. Immunoprecipitation of Shp-2 followed

• br Materials and methods br Results and discussion

  2019-07-02

  

  Materials and methods Results and discussion Conclusions Clitocypin is another member of the mycocypin family of cysteine protease inhibitors that is unique to tachykinin receptor shown to exhibit strong insecticidal activity against Colorado potato beetle larvae. This effect is concentrat

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