• br Methods br Results br Discussion br Conclusions br Confli

  2018-11-09

  

  Methods Results Discussion Conclusions Conflict of interest Acknowledgements The authors gratefully acknowledge the participation of healthy young volunteers in this Digoxigenin-11-ddUTP study. The authors of this study are funded by grants from the NIHR (LM: Academic Clinical Fell

• As summarized in Table our primary aim

  2018-11-09

  

  As summarized in Table 1, our primary aim was to quantify the test–retest reliability of a range of R-fMRI metrics in school-age children with and without ADHD. Several measures of test–retest reliability are available and have been used for R-fMRI (e.g., Thomason et al., 2011; Shehzad et al., 2009;

• gp120 br Neural inferences One area where precision is of

  2018-11-09

  

  Neural inferences One area where precision is of concern across the cognitive neurosciences is in the specificity of our neural inferences. As we previously suggested (Pfeifer and Allen, 2012), and as nicely summarized by Casey (2015) when considering several models related to dual-systems: “new

• Esa diferencia en la forma particular de inserci n a

  2018-11-09

  

  Esa diferencia en la forma particular de inserción a la nueva fase o –vía de desarrollo– se expresa en distintas formas de Estado y su accionar en la reproducción y el desarrollo económico; situación que ha dado lugar a la emergencia de antiguas y nuevas potencias económicas, como es el caso de Chin

• Our results provide evidence that i

  2018-11-08

  

  Our results provide evidence that (i) transcription factor NF-κB activation is necessary for limbal epithelial outgrowth on intact AM and MMP-9 expression (Fig. 4) and (ii) PI3-K/Akt and JNK pathways are involved in NF-κB activation (Figs. 5 and 6). Our data were supported by recent studies indicati

• br Materials and methods br Results br Discussion The

  2018-11-08

  

  Materials and methods Results Discussion The mechanisms of ADSC migration are still largely unknown. Migration of ADSCs in vitro is shown to be induced by several chemokines, VEGF, PDGF, LPA and TxA2 through activation of their biologically active receptors (Amos et al., 2008; Baek et al.,

• Here using an ectopic bone

  2018-11-08

  

  Here, using an ectopic bone model system, we found that: i) AFSCs do not contribute to bone healing by osteogenic differentiation or osteo-integration; ii) AFSCs are not retained in the bone microenvironment, do not affect the osteosynthesis, and do model the site in terms of vascular perfusion; iii

• In this study we used dermal fibroblasts

  2018-11-08

  

  In this study we used dermal fibroblasts derived from three different patients with distinct mutations in the TAZ1 gene (Houtkooper et al., 2009) and generated BTHS patient-specific iPSCs. We fully characterized them in terms of pluripotency both in vitro and in vivo. Similar to human ESCs, all gen

• In this study hPSC derived

  2018-11-08

  

  In this study hPSC-derived bfCNs were generated via an expandable NSC intermediate, which maintained the desired basal forebrain progenitor phenotype, and neurogenic capacity even after long-term expansion in culture. This scalability is a required feature of any cell type to be used in regenerative

• The potential of ES cells to

  2018-11-08

  

  The potential of ES dna staining to differentiate into DA neurons in vitro offers a simplified model system to dissect the mechanisms of cell intrinsic and extrinsic factors in DA neurogenesis, compared to the complex mammalian CNS (Baizabal and Covarrubias, 2009; Murry and Keller, 2008). Furthermo

• Previous in vitro characterization of compensatory TSC

  2018-11-08

  

  Previous in vitro characterization of compensatory TSC differentiation was performed at 20% O2 with a dose of benzopyrene or hyperosmolar stress that activated maximal stress enzyme (Zhong et al., 2010; Xie et al., 2010). When O2 levels are optimized, the highest growth and the least stress (activat

• br Materials and methods br Results br

  2018-11-08

  

  Materials and methods Results Discussion Recent neurogenesis studies and the discovery of multipotent neural stem purchase mecamylamine derived from the adult mammalian CNS, including that of humans, have had a considerable influence on potential treatments for neural injury (Gross, 2000; M

• br Summary and conclusions br

  2018-11-08

  

  Summary and conclusions Introduction Historically, the foundations of the concept that the heart is a static organ incapable of regeneration were established in the mid-1920s. A significant publication in 1925 claimed that mitotic figures are not detectable in human cardiomyocytes (Karsner et

• br Introduction Developmental myelination and

  2018-11-08

  

  Introduction Developmental myelination and myelin repair after demyelination are mediated by oligodendrocyte precursor cells (OPCs). OPCs are characterized by markers such as PDGFRα and the chondroitin sulfate proteoglycan NG2 (Dubois-Dalcq et al., 2008; Franklin and Ffrench-Constant, 2008; Nishi

• br Introduction The human gallbladder mainly

  2018-11-08

  

  Introduction The human gallbladder mainly functions to concentrate and store bile, and like anatomically close-by organs—the liver and the pancreas—is derived from the foregut endoderm during embryonic development (Spence et al., 2009). The extrahepatic biliary tree (comprising extrahepatic bile

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