• The HPA axis controls its own activity through

  2020-07-29

  

  The HPA axis controls its own activity through a negative feedback mechanism exercised by glucocorticoids (Keller-Wood, 2015), which limits the hypothalamic corticotropin-releasing factor (CRF) secretion and the pituitary estrone release (Keller-Wood, 2015). CRF binds to its specific receptors (cor

• Khan et al studied the effects of two structurally divergent

  2020-07-29

  

  Khan et al. studied the effects of two structurally divergent coumarins viz calipteryxin 3 and (3′S,4′S)-3′,4′-disenecioyloxy-3′,4′-dihydroseselin 4 from Seseli recinosum, in lipopolysaccharide (LPS)-stimulated murine macrophages. The study revealed that calipteryxin and (3′S,4′S)-3′,4′-disenecioylo

• Analysis of the known crystal

  2020-07-28

  

  Analysis of the known crystal structures of GPCRs shows that ligand binding affinity mostly occurs in a main cavity located between the extracellular segments of TMs 3, 5, 6, and 7 or in a minor binding cavity located between the EC segments of TMs 1, 2, 3, and 7. Despite these common pockets, diffe

• Genetically speaking oil accumulation in plant tissues is a

  2020-07-28

  

  Genetically speaking, oil accumulation in plant tissues is a complex quantitative trait that involves numerous genes. Efforts to increase oil yields in commercially valuable crops, such as E. guineensis and oilseeds like soybean, require the identification of the specific genes that regulate this hi

• br Role of DDR receptor in the development of Bone

  2020-07-28

  

  Role of DDR2 receptor in the development of Bone in human DDR2 receptor and MMP-13 expression Type II collagen protein in articular cartilage is highly stable structure as its half-life is 117 years [43]. The chondrocytes have limited ability to synthesis type II collagen protein in the matrix

• br Introduction Arsenic compounds or arsenicals

  2020-07-28

  

  Introduction Arsenic compounds or arsenicals are well-known toxic and carcinogenic agents (IARC, 1980, Wang et al., 2002). The genotoxic and co-genotoxic effects of inorganic arsenicals are well documented in mammalian systems, both in vitro (Jha et al., 1992) and in vivo (Tice et al., 1997). A n

• br Role of the funding source This work was supported

  2020-07-28

  

  Role of the funding source This work was supported by National Counsel of Technological and Scientific Development (CNPq); Foundation for Research Support of the State of Sao Paulo (FAPESP), Brazil (Grant number: 2010/07286-9). Conflict of interest Acknowledgments Introduction Corticotr

• Similarly research ranking RESEARCH was not significant in t

  2020-07-28

  

  Similarly, research ranking (RESEARCH) was not significant in the model so H7 is not supported. Contrary to the findings of Bline et al., 2016b, Boone et al., 2006, the current study did not find an association between faculty research productivity and exam pass rate. This could be due to difference

• Cy5.5 carboxylic acid (non-sulfonated) The second part of th

  2020-07-28

  

  The second part of this study evaluated the role of CK1 in the eFABP4 cellular uptake in endothelial cells. By blocking CK1 expression using a specific siRNA, we corroborated that the presence of CK1 was fundamental for FABP4 cellular uptake and internalization in endothelial cells, thus decreased m

• Over a century ago Dale

  2020-07-28

  

  Over a century ago, Dale [12] compared the effects of selected choline esters with the mushroom toxin, muscarine, and was the first to describe “muscarine-like” and “nicotine-like” actions. The relative potency of choline esters in isolated organ systems vs intact animals led him to posit that the “

• br Experimental br Results and discussion br

  2020-07-27

  

  Experimental Results and discussion Conclusion In this endeavour, a simple and cost-effective DNA-templated hydrothermal method was employed for the synthesis of high-performance electrochemical supercapacitive Bi2MoO6 electrode material. The structural properties of the prepared Bi2MoO6 ma

• br Phenotypic responses alkylation induced cell

  2020-07-27

  

  Phenotypic responses: alkylation-induced cell death and mutagenesis E. coli alkB mutants were isolated in a screen for strains specifically sensitive to the cytotoxicity of MMS but not UV-irradiation. This was the first indication that the AlkB protein is a primary cellular defence against alkyla

• br Acknowledgments Bhumika Bhatt Wessel s PhD

  2020-07-27

  

  Acknowledgments Bhumika Bhatt-Wessel\'s PhD was supported by a Victoria University of Wellington PhD scholarship and a research grant was provided by the Ministry of Science and Innovation (VLAC0801), New Zealand. Sonja Hummel helped with Fig. 2. Introduction The African oil palm, Elaeis guin

• br Cytokines and NK cells br

  2020-07-27

  

  Cytokines and NK cells Combined effects of cytokines and other stimuli on NK cell function Cytokine-stimulated NK desogestrel have enhanced capacity to kill tumor cells. However, usually, individual cytokines do not seem to be sufficient for full activation, proliferation, survival and effect

• br Clinical trials and treatments

  2020-07-27

  

  Clinical trials and treatments suggested from animal studies An open-label phase 2 clinical trial of cannabidiol in CDD and three other early life genetic epileptic encephalopathies suggested improvement in frequency of motor seizures >3 seconds in duration. The CDD group had a median reduction i

16320 records 817/1088 page Previous Next First page 上5页 816817818819820 下5页 Last page