• In addition to redox stress nutritional intake plays a key

  2022-04-11

  

  In addition to redox stress, nutritional intake plays a key role in modulating energy metabolism. DIO animal models are commonly used to study altered metabolic changes consequential to fat storage within various fat pads. In general, diets containing >40% high-fat lard, milk, and butter promote exc

• br Results and discussion br

  2022-04-11

  

  Results and discussion Conclusion In summary, starting from our previous lead FITC, Fluorescein isothiocyanate 1, we replaced the 5-nitropyrimidine core with pyrimidopyrimidine to obtain a series of novel compounds as drug candidates of GPR119 agonist for treatment of type 2 diabetes. Some de

• GPR A a G protein coupled receptor located mainly on

  2022-04-11

  

  GPR109A, a G-protein-coupled receptor located mainly on adipocyte cell membranes, has been identified as the molecular target for nicotinic beta-Nicotinamide mononucleotide receptor [[5], [6], [7]] and mediator of NEFA reduction [5]. As a mechanism of NEFA-lowering, it is recognized that activation

• The importance of FXR FGF signaling

  2022-04-11

  

  The importance of FXR-FGF15/19 signaling in BA homeostasis is illustrated by various BA malabsorption syndromes. Clinically, BA malabsorption causes diarrhea due to high BA concentrations in the colon that lead to secretion of water and electrolytes and stimulation of propulsive contractions [36]. P

• To determine the functional consequences of HIV gp

  2022-04-11

  

  To determine the functional consequences of HIV gp120 binding to vaginal epithelial cells, an annotation clustering of the differentially expressed genes was performed. The top enriched biological processes included an inflammatory immune response, defense response and the pathways included the SODD

• Accumulating studies revealed a decline

  2022-04-11

  

  Accumulating studies revealed a decline of TET1 expression in various cancers including breast, liver, colon, skin, prostate cancers [[36], [37], [38]]. Contrast to these studies, our previous research shows that TET1 is overexpressed in EC and improves the efficacy of chemotherapy in EC, coincide w

• br Membrane transporters as a novel

  2022-04-11

  

  Membrane transporters as a novel therapeutic target in pediatric TBI The concept of targeting membrane transporters began with identifying a neuroprotective drug and a corresponding transporter inhibitor. Somewhat serendipitously, we discovered that N-acetylcysteine (NAC), a cysteine donor for GS

• br Materials and Methods br

  2022-04-11

  

  Materials and Methods Results All of the studied transporter genes were expressed at detectable levels in all the analyzed samples at mRNA level by means of applied rt-PCR method (CTlowest Pomalidomide receptor was observed for ABCC4, ABCC1, ABCG2, SLC22A3, and SLC22A18 (less than 10% of mean

• br Vesicular glutamate transporters VGLUTs br Conclusions Du

  2022-04-11

  

  Vesicular glutamate transporters (VGLUTs) Conclusions Due to the molecular cloning of EAAT and VGLUT subtypes, a better understanding of the functional properties of these carriers has been elucidated over the last few years. In the case of the EAATs, specific blockers, such as trans-2,4-PDC,

• Historically a role for the prefrontal cortex

  2022-04-09

  

  Historically, a role for the prefrontal cortex in spatial working memory has been repeatedly claimed (for review, see Kolb, 1984). Older studies using traditional, non-fibre-sparing lesions (e.g. aspiration lesions) often resulted in spatial alternation deficits. In contrast, more recent studies emp

• br Introduction HH GLI signaling is one of the

  2022-04-09

  

  Introduction HH-GLI signaling is one of the major pathways involved in both normal and neoplastic development [[1], [2], [3], [4]]. Inappropriate activation of this pathway has been linked to cancer, including medulloblastoma, rhabdomyosarcoma, basal cell carcinoma and cancers of the lung, stomac

• brilliant blue Previous researches about ghrelin focused pri

  2022-04-09

  

  Previous researches about ghrelin focused primarily on gastrointestinal functions [30], energy balance [31], weight [32], and more recently on anxiety [33], [34], [35] and depression [36]. Here, we provided the first demonstration that chronic peripheral or central ghrelin treatment to CUMS rodents

• Taken together previous data suggest

  2022-04-09

  

  Taken together, previous data suggest that ghrelin signaling is causally linked to alcohol use and may regulate alcohol seeking and consummatory behaviors [[66], [67], [68]]. As such, the ghrelin system may represent a therapeutic target for AUD. Here, we provide a narrative review of the existing l

• br Materials and methods br Transparency document br Acknowl

  2022-04-09

  

  Materials and methods Transparency document Acknowledgments Introduction Hearing loss is the most common congenital sensory deficit. About 1–3 in 1000 children are affected at birth or during early childhood by severe hearing loss, which is defined as prelingual deafness, with at least h

• br Signals transmitted via MEGJ MEGJ facilitate the direct

  2022-04-09

  

  Signals transmitted via MEGJ MEGJ facilitate the direct transfer of ion currents or small molecules between EC and VSMC. Molecules passing through MEGJ are mainly second messengers such as Ca2+, IP3, and cAMP [31,32,] or endothelium-derived hyperpolarization (EDH) signals [34, 35, 36]. Moreover,

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