• br Conclusion br Introduction Multiple myeloma is a

  2019-05-10

  

  Conclusion Introduction Multiple myeloma is a malignant plasma cell disorder, comprising approximately 10% of all haematological malignancies, and its incidence is increasing [1]. The pathogenesis is complex, culminating in malignant transformation of clonal plasma cells. The aetiology is not

• In MM the optimal sequence or combination

  2019-05-10

  

  In MM, the optimal sequence or combination of the different therapeutic regimens available remains unclear and information is needed on the efficacy of each treatment after various prior therapies. Although a substantial number of different regimens and schedules were used for the treatment of first

• pri-724 br AML therapies with curative intent br Alternative

  2019-05-10

  

  AML therapies with curative intent Alternative treatment strategies Targeted therapies: the new kids on the block The recognition of specific mutations as genetic drivers or facilitators of AML has led to the development of new inhibitors and targeted treatment options. New promising drug c

• br AML therapies with curative intent br Alternative

  2019-05-10

  

  AML therapies with curative intent Alternative treatment strategies Targeted therapies: the new kids on the block The recognition of specific mutations as genetic drivers or facilitators of AML has led to the development of new inhibitors and targeted treatment options. New promising drug c

• The functional analysis of this V fsX mutation is shown

  2019-05-10

  

  The functional analysis of this V1764fsX1786 mutation is shown in Fig. 3B; no current was observed, indicating severe loss-of-function. Although we did not investigate the mechanisms of this complete reduction in Na+ current in this mutation, Herfst et al [19]. reported a similar frameshift mutation

• Although the CHADS score is useful for evaluating the risk

  2019-05-10

  

  Although the CHADS2 score is useful for evaluating the risk of stroke in NVAF patients, about half of all NVAF patients have a score of 0 or 1 [7]. There are no clear guidelines on whether warfarin should be administered or not, to these patients because the risk of annual incidence of stroke is so

• Clinical genetic electrocardiographic and electrophysiologic

  2019-05-10

  

  Clinical, genetic, electrocardiographic, and electrophysiological variables did not differ significantly between patients with and without the ER pattern (Table 2). Discussion Among our Brugada syndrome patients, the prevalence of the ER pattern was 10.1%, which is high in comparison to the 2%–5

• br Discussion GISTs originate from the interstitial cells

  2019-05-10

  

  Discussion GISTs originate from the interstitial RGDfK of Cajal. They occur commonly in the stomach (50–60%), the small intestine (30–35%), the colon and rectum (5%) and the esophagus (exon 11 is also associated with frequent tumor recurrence than with a PDGFRA mutation. Late recurrence of meta

• In WHO after realising the shortfall in appropriate medical

  2019-05-09

  

  In 2009, WHO, after realising the shortfall in appropriate medical devices in developing countries, called for innovative health technologies to address the technological gap between health-care settings in developed and developing countries. WHO\'s programme, the compendium of innovative health tec

• br Materials and methods br

  2019-05-09

  

  Materials and methods Results Discussion In recent years, it has been revealed that miRNAs are critical members of complex regulatory systems. SNPs or mutations occurring in the miRNA gene region may disturb the properties of miRNAs and result in defect in protein translation of target mRNA

• The concept of substrate mapping and ablation

  2019-05-09

  

  The concept of substrate mapping and ablation evolved from these surgical experiences. Unlike surgeons who can visually identify the infarct region, electrophysiologists must locate the abnormal region using the guidance of local ventricular electrograms. Marchlinski et al. reported that voltage map

• Successful and safe catheter ablation is facilitated

  2019-05-09

  

  Successful and safe catheter ablation is facilitated by an appreciation for anatomical particularities and surgical details. Morphological analysis of clinically documented VT is also important. In these patients, VT usually shows a left bundle branch block-like QRS morphology and inferior frontal p

• br Methods br Results br Discussion br

  2019-05-09

  

  Methods Results Discussion Conclusions Conflict of interest statement Introduction Pulmonary vein (PV) isolation using a conventional electrode catheter is an effective therapy for atrial fibrillation (AF) [1,2]. However, it requires a long procedure time and has occasionally been

• Clearly there are limitations to

  2019-05-08

  

  Clearly there are limitations to the current study. These include the single centre, retrospective nature of the study as well as its relatively small sample size compared with the randomised data. However, the duration of follow up is considerably longer than these trials (Table 1). In conclusion,

• br Methods br Results br Discussion Analyses of basal

  2019-05-08

  

  Methods Results Discussion Analyses of basal syndecan-1 expression showed differences in syndecan-1 levels as well as staining pattern for this proteoglycan in the breast cancer cell lines that were employed. Different localization of syndecan-1 have been found in previous studies showing l

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