• β(1,3)-d-glucan synthase GSC reprogramming takes place over

  2018-10-24

  

  GSC reprogramming takes place over multiple weeks and the mechanism is largely unknown. Low efficiency and inconsistent ESL cell formation makes it difficult to study the molecular mechanism of GSC reprogramming, knowledge of which is a prerequisite for improving the efficiency. In addition, GSCs do

• Regardless of the detailed mechanisms of metabolic regulatio

  2018-10-24

  

  Regardless of the detailed mechanisms of metabolic regulation in ESCs, recent studies indicate that reprogramming MEFs into iPSCs involves dramatic changes in cell metabolism from oxidative phosphorylation to glycolysis (Folmes et al., 2011). Somewhat paradoxically, however, the early phase of the m

• Given the importance of the

  2018-10-24

  

  Given the importance of the master regulatory HOX genes for patterning during embryogenesis, we expect that the ectopic expression of a specific HOX code could allow for enhanced development of desired tissues in vitro. One example is human HOXB4, which is highly expressed in the hematopoietic stem

• To investigate whether the activated pathways identified in

  2018-10-24

  

  To investigate whether the activated pathways identified in ALS MNs were causal or merely associated with the disease phenotype, we assayed MN survival in vitro after pharmacological inhibition of the identified pathways. MNs differentiated from mutant SOD1 iPSCs were treated with small-molecule inh

• where a is a radius

  2018-10-24

  

  where a is a radius of the circular contact (probe); r is a distance from the center of the contact – probe place to the hemispherical contact; ρ is a resistivity of the area between the contacts. Spreading resistance R is well approximated for a homogeneous semi-infinite doped sample with resistan

• Acceleration of neutrons in the uniform magnetic field by me

  2018-10-24

  

  Acceleration of neutrons in the uniform magnetic field by means of a radio-frequency flipper is well known and successfully used in physical experiments (see, e.g., Ref. [7]). The phenomenon of neutron acceleration in a strong alternating magnetic field (of amplitude ∼0.4T) was observed in Ref. [8].

• kv1.3 inhibitor The results of epitope mapping and

  2018-10-24

  

  The results of epitope mapping and limited proteolysis are also consistent with the results of computer analysis of the sequence. To date, two alternative topological models have been proposed, differing from each other by the orientation of receptor insertion into the lipid bilayer (Fig. 2b and c)

• br Funding and conflict of interest statements br

  2018-10-24

  

  Funding and conflict of interest statements Acknowledgements We would like to acknowledge funding received from the Canadian Institutes of Health Research (award number GSD-134926) and the Lawson Foundation, Canada (grant number GRT 2011-013). We would also like to thank Dr. Mieke Koehoorn for

• Aside from differences between countries differences also ex

  2018-10-24

  

  Aside from differences between countries, differences also exist within countries. Indeed, recent research shows that in many African countries attitudes related to female genital cutting vary substantially at the individual and household levels (Bellemare et al., 2015; Efferson et al., 2015; Hernlu

• Kearney and Levine present a detailed survey of teenage

  2018-10-23

  

  Kearney and Levine (2012) present a detailed survey of teenage childbearing in the US. The main conclusion is that both actual and perceived lack of economic opportunities influence early motherhood. After these factors have been taken into account, teenage motherhood does not appear to cause additi

• Currently there are no medications or modalities to reduce

  2018-10-23

  

  Currently, there are no medications or modalities to reduce both visceral adiposity as well as chronic inflammation in MS or T2DM subjects. Recently, we (Morino et al., 2008a; Adachi et al., 2010) and others (Chung et al., 2008; Gupte et al., 2009) have shown that the beneficial metabolic advantages

• br Funding This work was supported by the

  2018-10-23

  

  Funding This work was supported by the NSF fellowshipDGE0909667 (P.J.H.) and the NIH fellowshipDA 035535 (P.J.H.), NIH grants DA038058 and DA012408 (A.G. & U.G.) as well as by the Danish Council for Independent Research Medical Sciences) (U.G.). N.G.C. was supported by the Training Program in I

• Our study reveals additional aspects of

  2018-10-23

  

  Our study reveals additional aspects of innate pre-conditioning and pitavastatin in neutrophils. Neutrophil is a key innate leukocyte, and its modulation bears critical relevance to the outcome of sepsis (Stearns-Kurosawa et al., 2011). Neutrophils have multiple functions that include cytokine expre

• br Materials and Methods br Results

  2018-10-23

  

  Materials and Methods Results Discussion In this study, we examined the cancer genomes of HPR NSCLCs to identify the genomic mutation profile associated with prolonged exposure to smoky coal pollutants. Of the 14 WGS patients, there was a mean of 12.75somaticgenomicmutations/Mb, 8.16exonicm

• br Materials and Methods br Results br Discussion

  2018-10-23

  

  Materials and Methods Results Discussion In this study, we identified several key developmental and stem cell regulatory genes as potential biomarkers of arsenic exposure in the fetal placenta. Our results also revealed extensive sexual dimorphism in the associations between placental gene

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