• br Conflict of interest br Acknowledgments This study was

  2018-10-25

  

  Conflict of interest Acknowledgments This study was funded by the UK Medical Research Council (MRC) (G0802226) and the Behavioural and Clinical Neuroscience Institute (BCNI) at the University of Cambridge (jointly funded by the MRC and Wellcome Trust). Additional support was given by the Natio

• br Plasticity sensitive periods and alternative developmenta

  2018-10-25

  

  Plasticity, sensitive periods and alternative developmental trajectories (Question 4) Although there is currently little direct evidence on this issue for autism, examples where transient adaptations have life-long consequences for calcifediol development are common. For example, disruption to t

• One clear limitation to the

  2018-10-25

  

  One clear limitation to the present study is the sample size. As a result, while conventional thresholds and covariates were used in statistical models to correct for Type I error, there remains a chance for Type II error, or the chance that analyses were underpowered to detect smaller but meaningfu

• br Discussion In Adachi et al described the first case

  2018-10-25

  

  Discussion In 1994, Adachi et al described the first case of BPDCN in a Japanese male with cutaneous CD4+ lymphoma. Since then, Petrella et al and other groups have reported additional cases and re-characterized the immunophenotypic and histological features of BPDCN. The nomenclature of such CD4

• dnmt One unexpected benefit of this analysis was that

  2018-10-25

  

  One unexpected benefit of this analysis was that it dnmt illustrated the precision of the AFVA method to measure projectile orientation. Previously, it was determined that AFVA measurements were within 0.1° of on-board electronic measurements [5], but clearly the data from this test smoothly show f

• Siguiendo un modelo t pico de interiorizaci n Monsiv is

  2018-10-25

  

  Siguiendo un modelo típico de interiorización, Monsiváis piensa las consecuencias como previas PLX 4032 las causas. Si lo que surge de ese estigma triturador es una interiorización de “numerosos elementos de la homofobia” y también una subordinación a lo que llama “dispositivos del prejuicio”, enton

• Al respecto Baudrillard se ala

  2018-10-25

  

  Al respecto, Baudrillard (1969) señala que esta totalidad es de orden moral, porque ahí quedarán materializadas las relaciones personales del grupo que cohabita en ese continente espacio-objetual. Sin embargo, Baudrillard olvida mencionar que estas relaciones son también relaciones de poder, y que l

• Trabajos como el de Chandra

  2018-10-25

  

  Trabajos como el de Chandra Talpade Mohanty (2008) van en esta misma dirección cuando muestran que, desde las posiciones marginales, se pueden interrogar las identidades hegemónicas. Para ella, se puede leer la escala ascendente del privilegio, acceder y hacer visibles los mecanismos del poder GSK11

• iPSC derived iHLCs offer a

  2018-10-24

  

  iPSC-derived iHLCs offer a unique advantage in that they can be generated from any donor, which allows a broad spectrum of the human population to be represented in in vitro drug screens and provides an opportunity to assess donor-specific drug responses in vitro. Recent collaborations between drug

• In the present study enzyme

  2018-10-24

  

  In the present study, enzyme activity was dispensable for reprogramming and iPSC maintenance. This is in contrast with Fanconi anemia (Raya et al., 2009; Navarro et al., 2014), and also with Sanfilippo type B (Lemonnier et al., 2011) and Pompe disease (Higuchi et al., 2014), in all of which gene com

• The pituitary gland is considered the master gland of hormon

  2018-10-24

  

  The pituitary gland is considered the master gland of hormone function. Hypopituitarism is a disease condition with insufficient or absent function of the pituitary gland. Pituitary tumors are the most common cause but many other triggers can induce pituitary dysfunction including inborn genetic def

• gp120 Main Text Stem cell research remains an

  2018-10-24

  

  Main Text Stem cell research remains an exploding area of investigation with the potential to change human health. As the field continues to grow, so does the ISSCR and its role as the world’s largest professional organization of stem cell scientists. Our mission to promote good science and respons

• br Results br Discussion In the meibomian gland low numbers

  2018-10-24

  

  Results Discussion In the meibomian gland, low numbers of LRCs were observed after 28, 42, and 56 days of chase, which fulfill the slow-cycling, undifferentiated, and low population criteria of adult epithelial stem kit inhibitor characterized in other tissues (Alonso and Fuchs, 2003; Stepp a

• The ensuing replication stress during rapid expansion elicit

  2018-10-24

  

  The ensuing replication stress during rapid expansion elicits a broad DDR, when Fancd2-deficient HSPC accumulate DNA damage and activate p38 MAPK in response to physiological replication demands encountered during development. The lack of a more robust γH2AX phosphorylation seemed initially surprisi

• procyanidin b2 The distinct epigenetic and molecular profile

  2018-10-24

  

  The distinct epigenetic and molecular profile of PDGFRα+ subpopulations was confirmed also by their developmental potential (Figure 5 and Table S1). The double-positive procyanidin b2 could still colonize the epiblast while PrE-primed cells exclusively contributed to PrE derivatives. Again, these i

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